Stephen T., M.D. Sinatra
See book keywords and concepts |  Low levels of hgh, which is secreted by the pituitary gland, are associated with age-related changes such as weight gain, sagging skin, and a fall in libido. Further, a deficiency can result in diminished immune capacity, lower energy levels, sleep difficulties, short-term memory loss, and even a predisposition to cardiovascular disease.
At the December 1996 Anti-Aging Conference in Las Vegas, Nevada, I heard Dr. Bengt-Ake Bengtsson, one of the leading human growth hormone researchers in the world, discuss his landmark study of 333 patients with low levels of hgh. Dr. |
Jeffrey M. Smith
See book keywords and concepts |  For people with pituitary deficiency, bGH treatments produced some changes "similar to those effects noted after administration of hgh." The FDA should have known this, as this quote appeared in a new drug application submitted to the FDA in 1987 by Elanco—for their brand of rbGH. Another study also showed other minor changes in human physiology resulting from bGH.
Irrespective of whether bGH levels increase, influence humans, or are mixed with the genetically modified variety in milk, the FDA assures us that there is still no problem. |
Sheldon Saul Hendler and David Rorvik
See book keywords and concepts |  ACTIONS AND PHARMACOLOGY
ACTIONS
Supplemental hgh and secretagogues or releasers have putative anabolic and lipolytic activities, as well as putative "anti-aging" activity.
MECHANISM OF ACTION
The mechanism of the putative actions of supplemental hgh and secretagogues or releasers is unknown. The actions of endogenous GH and parenteral GH are thought to be mediated via the anabolic hormone IGF-1 and by interaction with specific GH receptors that are widely distributed in body tissues.
PHARMACOKINETICS
Orally administered GH has very poor bioavailability. |
Stephen T., M.D. Sinatra
See book keywords and concepts | | In the March 28, 1996 issue of the New England Journal of Medicine, Italian investigators reported that seven cardiomyopathy patients who received hgh by injection all increased the percentage of blood pumped from the left ventricle with each heartbeat, an improvement that translated into enhanced feelings of well-being and quality of life.
HGH therapy of this nature, however, needs to be given under the administration of a physician. The therapy costs approximately 100 to 250 dollars a week and usually lasts for six months. |
The Life Extension Editorial Staff
See book keywords and concepts |  Researchers theorize that hgh increases blood flow to the brain, regenerates neuronal dendrites and axons, and helps to rebuild protein that leads to the formation of RNA and DNA (Shippen et al. 1998).
An article in the journal Neurology described a study of the hormonal patterns in eight stroke patients and five matched healthy volunteers. Nocturnal plasma hormone measurements showed low growth hormone levels and elevated prolactin concentrations. Cortisol levels, however, were normal. | | HGH therapy is administered and monitored by an antiaging specialist.
W PRODUCT AVAILABILITY
Alpha-lipoic acid, CLA (and CLA with guarana), creatine monohydrate, HMB, DHEA, Enhanced Whey Ptotein, phosphatidylserine, acetyl-L-catnitine, glutamine, Super GLA/DHA, and CoQjrj, can be ordered by calling (800) 544-4440 or by ordering online at www.lef.org. | | However, note should be made that many studies have shown a worsening of outcome when hgh is used in the period of critical illness. While growth hormone wotks well to improve healing if begun before the wound occuned, in the case of a critical injury (as a burn or renal transplant), growth hormone begun at the time of the injury has shown a worsening of outcome.
Fibroblast Growth Factor-10 (FGF-10)
Application of FGF-10 improves wound strength, collagen content, and epidermal thickness (Jimenez et al. 1999). |
Stephen T., M.D. Sinatra
See book keywords and concepts | | Among patients treated with hgh replacement therapy, there was a uniform decrease in cardiovascular risk, as well as weight loss and a favorable increase in HDL and lower LDL blood fractions.
Another promising aspect of hgh is its ability to improve congestive heart failure. | | However, you can increase your hgh naturally by either fasting, exercising, or taking niacin in combination with amino acids. As little as 200 mg of niacin has been known to increase hgh secretion. Amino acids such as L-arginine, L-glutamine, and L-ornithine have also been shown to have a dramatic effect. These amino acids can be taken on an empty stomach, one hour prior to exercise, or before sleep. You can find these nutrients in almost any health food store, and there are no side effects at the recommended doses of 1 to 2 grams each. | | For an excellent book on hgh, I would suggest Grow Young with hgh by Dr. Ronald Klatz.
A STRATEGY OF PREVENTION
The search for the fountain of youth has been going on for centuries. Today, people are especially concerned with delaying the process of aging. In my mind, the best method for halting disease and delaying aging is prevention. A good prescription for disease prevention and antiaging tactics includes a healthy diet: targeted nutritional supplementation with vitamins, minerals, and herbs; chlorophyll-containing foods; and mild to moderate exercise regimens. |
The Life Extension Editorial Staff
See book keywords and concepts | | If hgh is not affordable, consider supplementing with 75-100 mg of DHEA during the healing process. Refer to the DHEA Replacement protocol for details.
11. For chronic or serious wounds, consider alternative treatments such as hyperbaric oxygen therapy, whirlpool therapy, ultrasound treatment, electrical stimulation, magnetic therapy, and therapeutic touch.
12. For wounds and fractures that do not heal as expected, it might be beneficial to seek help from a university orthopedic or plastic surgery section using local application of growth factors and new drugs that affect growth factors. |
Stephen T., M.D. Sinatra
See book keywords and concepts | | For an excellent book on hgh, I would suggest Grow Young with hgh by Dr. Ronald Klatz.
A STRATEGY OF PREVENTION
The search for the fountain of youth has been going on for centuries. Today, people are especially concerned with delaying the process of aging. In my mind, the best method for halting disease and delaying aging is prevention. A good prescription for disease prevention and antiaging tactics includes a healthy diet: targeted nutritional supplementation with vitamins, minerals, and herbs; chlorophyll-containing foods; and mild to moderate exercise regimens. |
Ronald Klatz and Robert Goldman
See book keywords and concepts |  People who have taken hgh have found it to produce striking improvements in their health, energy level, and sense of well-being. The list of benefits seems to grow with each new study. It now includes:
45
• younger, thicker skin
• stronger bones
• an average gain of 8.8 percent in muscle mass after six months, without exercise
• an average loss of 14. |
David Brownstein
See book keywords and concepts |  Grow Young With hgh. Harper Collins, 1995, p. 36
2 Journal of NIH Research, Adapted from, April, 1995
3 Rudman, Daniel, et al. Effects of growth hormone in men over 60years. New England Journal of Medicine, 323, 1-6, 1990
4 Rudman, Daniel. IBID.
5 Beshyah, S.A., et al. Abnormal body composition and reduced bone mass in growth hormone deficient hypopituitary adults. Clinical Endocrinology (42): 179-189, 1995
6 Fazio, S., et al. A preliminary study of growth hormone in the treatment of dilated cardiomyopathy. New England Journal of Medicine. 334: 809-14, 1996. |
Ronald Klatz and Robert Goldman
See book keywords and concepts | | Likewise, taking hgh supplements (or their equivalents) is no substitute for watching what you eat and reducing fat, and perhaps calories, in your daily diet.
"Anti-aging has long been equated with trying to live longer, but if we can move the emphasis away from death prevention and towards quality of life, then I don't see anything wrong with that," says George Annas, a Boston University bioethicist. "We all have to age, but the aged should be allowed to age gracefully." Human GH alone is not the antidote to aging, but it may contribute to living more productively for many of the elderly. |
Dharma Singh Khalsa, M.D.
See book keywords and concepts |  Very few of my patients have used synthetic hgh, because of its cost, but those who have used it have responded quite positively.
Tacrine. Currently approved by the FDA as a treatment for Alzheimer's, tacrine has shown positive results in a number of studies. Tacrine stimulates the cholingeric system by inhibiting an enzyme (cholinesterase) that breaks down acetylcholine.
Recent studies indicate that tacrine is more effective when used in conjunction with a choline product, such as lecithin. |
Ronald Klatz and Robert Goldman
See book keywords and concepts | | By the time you're 60 or 70, your body has access to only 15 to 20 percent of the hgh that it used in your youth.
Human GH's primary function in childhood and young adults is to help bones lengthen and expand, so that from infancy until our mid-twenties, we are growing, becoming taller, longer-limbed, stronger-boned. Human GH also promotes growth by helping to transport amino acids between cells and by inducing cells to accept and synthesize amino acids. | | The growth hormones that help us form muscle mass, hgh, testosterone and thyroid, for example, drop dramatically as we age, so that even if an elderly person has not gained weight, he or she has undoubtedly increased the ratio of fat to muscle.
Hormones are vital for repairing and regulating our bodily functions, and when aging causes a drop in hormone production, it causes a decline in our body's ability to repair and regulate itself as well. | | She cautions users of hgh that, because there are so many unanswered questions about the use of the hormone in the elderly and in adults with growth hormone deficiency, its general use now or in the immediate future is not justified. Furthermore, there is potential for widespread abuse in healthy adolescents and adults.
Dr. Richard Cutler, a gerontologist at the National Institute on Aging in Bethesda, Maryland, is even more specific, suggesting that the age-related decrease of growth hormone may be a positive phenomenon that doctors shouldn't tamper with. | | Other key functions of hgh include:
• Breaking down body fat. When children are growing, it's important that the nutrients they ingest be converted to bone, muscle, and organ tissue, not to fat. The natural human GH their body produces is crucial to this process.
• Synthesizing collagen, the substance in our body that keeps us flexible and limber. Collagen strengthens our cartilage, tendons, ligaments and bones. As children grow up, they can stretch their bodies to do more things, whereas as adults become older, they tend to stiffen up, partly because of a loss of collagen. |
J. E. Williams, O.M.D.
See book keywords and concepts |  Along with DHEA, it can buffer negative effects of stress hormones and enhance the activity of hgh, and the thyroid and thymus glands.
The thymus is the most important immune gland; enhancement of thymic hormones may be the linchpin in your viral immunity program.
Improving thyroid function can improve your entire hormonal system.
Hormones work synergistically. Do not supplement one without another, but only work with those you need. To work best, hormone therapy should be tailored to your individual metabolism. |
James A. Howenstine, MD
See book keywords and concepts |  L-glutamine Aids in health and growth of muscle tissue as well as releasing hgh.
L-glycine Corrects hyperacidity, aids in construction of RNA and DNA and stabilizes heart and muscle function after heavy exercise.
L-cystine stimulates white blood cell function for disease resistance, needed for skin formation and promotes healing after surgery and burns.
L-taurine assists in lowering blood pressure, lowering cholesterol and triglycerides, and has a calming effect.
L-valine Found in high amounts in muscle tissue.
L-tyrasine Precursor substance for adrenaline and thyroid hormones. |
David Brownstein
See book keywords and concepts | | Grow Youns With hgh. by Ronald Katz, M.D. (Harper-Collins, 1997)
Hypothyroidism, The Unsuspected Illness, by Broda O. Barnes, M.D. (Harper and Row, 1976).
Living Well With Hypothyroidism. Mary J. Shomon (Avon Books, Inc. 2000)
Maximize Your Vitality and Potency, Jonathan Wright, M.D. and Lane Lenard, PhD (Smart Publications, 1999)
Melatonin: Nature's Sleeping Pill, by Ray Sahelian, M.D. (Avery, 1996).
Natural Hormone Replacement for Women over 45. Jonathan Wright, M.D. and John Morgenthaler. (Smart Publications, 1997)
Overcoming Arthritis, by David Brownstein, M.D. |
John Boik
See book keywords and concepts |  Symptoms generally include cough, sputum production, hemoptysis, stridor, infection, and paraneoplastic syndromes (ACTH and hgh irregularities, etc.). Regional and distant spread is common. The course is
FIGURE H.6. RELATIVE SURVIVAL RATE FOR PATIENTS WITH CANCERS OF THE LUNG AND BRONCHUS
0 2 4 6 8 10 12 14 16
Year after diagnosis
TABLE H.4. DISTRIBUTION AND SURVIVAL RATES FOR PATIENTS WITH CANCER OF THE LUNG AND BRONCHUS
All stages
100
13.1
Localized
16
45.6
Regional
32
13.1
Distant
37
1.3
Unstaged
15
7. |
Ronald L. Hoffman, M.D.
See book keywords and concepts |  Bill Lawren (New
York: Regan Books, HarperCollins, 1995) Grow Young with hgh by Ronald Klatz (New York: HarperCollins, 1997)
Professional and Support Organizations
The Broda Barnes Foundation (203) 261-2101
Diagnos-Tech Clinical and Research Laboratory 6620 South 192nd Place Kent, WA 98032 (800) 878-3787
Web Site http://www.endocrine.org All-over resources Health Products
DHEA-25: PhytoPharmica, Green Bay, WI 54311
Hopewell Pharmacy: Innovative formulator of natural hormone preparations, (800) 792-6670
Chapter 7. |
Sheldon Saul Hendler and David Rorvik
See book keywords and concepts | | There is some fear that high doses of hgh might promote some cancers.
RESEARCH SUMMARY
Recombinant human growth hormone, given parenterally to men aged 61 to 81, reportedly resulted in significant improvements in lean body mass, muscle tone, skin thickness and density of lumbar vertebrae. Significant loss of adipose tissue was also reported. The researchers concluded that "the effects of six months of human growth hormone treatment on lean body mass and adipose tissue were equivalent in magnitude to the changes incurred during 10 to 20 years of aging. | | Recombinant hgh or somatropin is also used for the treatment of GH deficiency in adults, short stature in association with renal insufficiency, AIDS-related wasting and short stature associated with Turner's Syndrome. In all of these cases, GH must be administered parenterally since it has very poor oral bioavailability.
GH is the primary hormone responsible for growth in humans, as well as other mammals, and it helps regulate such metabolic processes as anabolism and lipolysis. Normal human aging is associated with decreased GH secretion. | | Recently, hgh has entered the dietary supplement marketplace, as have IGF-1 (see Insulin-Growth Factor 1) and several so-called GH secretagogues or releasers. The substances being marketed as GH secretagogues or releasers include the amino acids L-arginine, L-glutamine, L-orni-thine, glycine, L-dopa, as well as such substances as ornithine alpha-ketoglutarate (see Ornithine Alpha-Ketoglu-tarate) and the herbs Macuna pruriens and Tribulus terres-tris. |
Larry Trivieri, Jr.
See book keywords and concepts |  It is also important to closely monitor thyroid hormone levels, as elevated levels of hgh tend to boost the body's metabolic rate. This can lead to an increased consumption of thyroid hormone, potentially causing hypothyroidism.
Conditions Benefited by Natural Hormone Replacement Therapy
Research has shown that the use of natural hormones can provide benefit for numerous disease conditions.
ESTROGEN AND PROGESTERONE
According to Dr. |
J. E. Williams, O.M.D.
See book keywords and concepts | | The abnormal fluid retention that hgh can cause in some people may result in carpal tunnel symptoms (severe tingling of the forearms, inside of the wrists, and palms of the hands). Both psychological stress and the distress associated with chronic viral disease affect water balance in the body and kidney function, and both physical and psychologistamina, foweredimmune'function, and premature aging. blood. Urinary tests that measure growth hormone are available, but are not in common use yet. |
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