Samuel S. Epstein, M.D.
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 Genetically Engineered Anti-Aging Medication Poses Undisclosed Cancer Risks Press Release March 14,2000
Use of the genetically engineered (recombinant) human growth hormone (rHGH) for anti-aging medication has become a major growth industry. Suppliers of HGH, including those offering mail order prescriptions, are proliferating on web sites and the Internet. |
| Neither natural nor synthetic bovine growth hormone has been found to affect human growth hormone receptors. Rather, concerns about the potential cancer risk to humans relate to the potential absorption of bovine IGF-1, which has identical amino acid sequences and biological effects in cows and people. Human IGF-1 has attracted considerable research attention in recent years as potential promoter of certain cancers.
Absorption of IGF-1 from rBST Treated Milk: FDA and other organizations have examined three questions regarding IGF-1 exposure from rBST-treated milk. |
| This contrasts with recognition by FDA and industry of immunological evidence on gastrointestinal absorption of intact proteins (4, 17), and on the high incidence of allergenic and immunogenic effects induced by recombinant methionyl human growth hormone, (7, 18). |
Peter Rost
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 FOUR
Crimes and Misdemeanors
From the beginning of my time at Pharmacia, the flagship drug of my endocrinology franchise had been Genotropin, a human growth hormone. Though we sold it for use in both short children and adults with growth hormone deficiency, the big market was children—they had to inject the drug daily for many years until they reached their adult height. A patient base like that made for stable sales that didn't fluctuate a lot. Our only worries were our three major competitors, each with their own genetically engineered growth hormone, virtually identical to ours. |
Samuel S. Epstein, M.D.
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| The authors warned against the risks of administration of human growth hormone or IGF-1 for anti-aging purposes.
Yu & Rohan, J Natl Cancer Inst 92:1472-1484, 2000
In a comprehensive literature review, the authors reported elevated IGF-1 levels in all of five publications on prostate cancer, with excess risks ranging up to over 4-fold. The authors stressed that "elevated levels of IGF-1 in the circulation are associated with increased risks for several common cancers. |
Byron J. Richards, CCN
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 In a smaller recent study treating 30 AIDS patients with recombinant human growth hormone (rhGH) in an effort to reduce their stomach fat, four of them developed diabetes and three of them developed cancer.432
GROWTH HORMONE AND DIABETES
Problems with GH and IGF1 lead to insulin resistance and diabetes.433 Remember that GH and insulin come from the same family tree and look almost identical. Scientists found that the reason GH causes insulin resistance is that it binds to insulin receptors, clogging their function. |
Eric R. Braverman
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 While the hormones listed below are necessary to enhance any nature, a dopamine nature will notice more readily when they require supplementation. human growth hormone (HGH) is available in injectable form and is very expensive. A less expensive alternative is to augment existing HGH with amino acid products such as creatine and arginine. All of the following natural hormones help increase voltage and provide energy to the brain. They also have other specific functions. |
Joan Liebmann-Smith, Ph. D., and Jacqueline Nardi Egan
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 More commonly, it's seen in people who are obese, in which case it may point to insulin resistance. It's often an important early warning sign of diabetes. In
(PCOS), the most common hormonal disorder in women of reproductive age and a leading cause of infertility. (See Chapter 1.) AN is also sometimes seen in people with Cushing's syndrome, a hormone disorder of the adrenal glands. (See Black-and-Blue Marks, above). |
Samuel S. Epstein, M.D.
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| While BGH is inactive in all primates, it should be noted that human growth hormone is only active in humans when given in high (mg) doses. Moreover, no studies on humans have been conducted with the synthetic hormones, especially the more potent met-BGH. Furthermore, it was demonstrated some 30 years ago that chymotrypsin digests of natural BGH are biologically active in humans, in whom they induce nitrogen retention (Forsham et al, 1958). |
Phyllis A. Balch, CNC
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 Considerations
Q human growth hormone (HGH) has been shown to improve brain function. (See growth hormone therapy in Part Three.)
Q Some medications may have an adverse effect on memory, including beta-blockers, benzodiazepines (prescribed for anxiety), some painkillers and antihistamines, and anticholinergics (prescribed for incontinence or depression).
Q Occasional memory loss or forgetfulness is common. |
Kaayla T. Daniel, PhD, CCN
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 Clinicians are recommending both products to prevent and reverse dementia, improve cognitive function, increase human growth hormone (hGH) release, and to treat brain disorders such as damage
SOY, SOY EVERYWHERE, DROPS OF SLUDGE TO EAT
Try to find a chocolate bar, ice cream or other readymade food at the supermarket or health food store that doesn't contain small amounts of soy lecithin. That's the challenge for people who are allergic to soy. Lecithin isn't supposed to contain any of the soybean's allergenic protein, but there's always the chance that a bit might remain. |
Michael Friedman, ND
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 For example, human growth hormone (hGH) lowers total cholesterol, while increased Cortisol levels have the opposite effect. Menopause is known to decrease HDL, while LDL levels rise. Hyperlipidemia is a standard screening test for thyroid dysfunction. Recently, Gerald Reaven at Stanford University discovered that hyperinsuline-mia (Metabolic Syndrome X) raises triglycerides and LDL levels, thereby increasing cardiovascular risk. Clearly, consideration of endocrine function is important in assessing any dyslipedemia. |
| NATUROPATHIC MEDICAL TREATMENT AND PREVENTION
In addition to standard growth hormone injections, amino acid therapy is recommended to help stimulate human growth hormone level. The use of arginine intravenously has demonstrated to be effective in increasing growth hormone levels. Orally 5 g and 9 g of arginine caused a significant GH response. However, at higher doses, such as 13 g, digestive side effects occurred with no further increase of GH stimulation. The rise in GH concentration occurs within 30 minutes and peaks at 60 minutes after oral ingestion. |
| Effects of human growth hormone in men over 60 years old. New Eng. J. of Med 1990;323:1-6.
5. Ehrnborg C, Ellegard L, Bosaeus I, Bengtsson BA, Rosen T. Supraphysiological growth hormone: Less fat, more extracellular fluid but uncertain effects on muscles in healthy, active young adults. Clin Endocrinol (Oxf). 2005 Apr;62(4):449-57.
6. Collier SR, Casey DP, Kanaley JA. Growth hormone responses to varying doses of oral arginine. Growth Horm IGF Res. 2005 Apr;15(2):136-39. Epub 2005Jan 26.
7. Harmany Equine Clinic, Ltd, Washington, Virginia 22747, USA. |
Mike Adams, the Health Ranger
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 We have a lot of natural hormones available right now as nutritional supplements including Melatonin, DHEA and even injectable human growth hormone (although some would certainly argue the long-term safety and efficacy of some of these as well).
But I believe that it is inherently safer to put natural hormones into the human body rather than synthetic chemicals. So from the get-go, PYY3-36 has one obvious advantage. It's something that we already have in our bodies. So what's the promise of this prescription drug?
The promise is that by inhaling this protein, your appetite will be reduced. |
Byron J. Richards, CCN
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| Infomercials touting the benefits of taking human growth hormone saturate the media. It is promoted as the fountain of youth. In the hands of the uninformed, it may just as well be the fountain of death.
There is no question that GH levels decline with age. Likewise, overweight individuals have seriously handicapped GH function. Lack of GH activity promotes weight gain around the midsection, the worst possible type of weight to gain.418 As GH levels decline, the cardiovascular risk picture significantly worsens.419
GH can be measured in the blood to establish a lack of the hormone. |
Phyllis A. Balch, CNC
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| Human growth hormone therapy has been found to decrease cholesterol levels. (See growth hormone therapy in Part Three.)
Q Many fast-food restaurants use beef tallow (fat) to make their hamburgers, fish, chicken, and French-fried potatoes. Not only do these fried foods contain high amounts of cholesterol, but this fat is subjected to high temperatures in the deep-frying process, resulting in oxidation and the formation of free radicals. |
Eric R. Braverman
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| TREATING MEMORY DISORDERS WITH HORMONES
Hormones associated with the memory function include human growth hormone, vasopressin, DHEA, and pregnenolone, as well as estrogen and testosterone. Hormone assessment and balancing should be included in a treatment plan for severe memory impairment.
Women can experience different types of memory problems than men due to the influence of estrogen, progesterone, and other hormones. Estrogen receptors are present in several regions of the brain involved in memory and attention, including the temporal and frontal lobes. |
Phyllis A. Balch, CNC
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| Human growth hormone treatment can improve kidney function. (See growth hormone therapy in Part Three.)
Q Recurrent urinary tract infections indicate the possibility of a serious underlying problem. See your health care provider.
Q High doses of the painkiller ibuprofen (Advil, Nuprin, and others) can lead to kidney dysfunction.
Q A home dialysis system is available for those requiring dialysis treatments.
Q See also bladder infection and kidney stones in Part Two. |
Joseph E. Mario
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 B6 for daily synthesis with human growth hormone (HGH) and Insulin, Vitamin C, and essential fat Linoleic acid joining with sulfurous Proteins, vital for Protein metabolism; with Chromium, Zinc, Calcium, Magnesium, Potassium, and Copper for use of the Amino acids; Carbohydrates are Protein-sparing; work with most Vitamins and Minerals for metabolism and precursing. Amino acids are always taken with extra Vitamins, B6, Minerals, and Water.
RANGE: 35-50 Grams per day; or .213 grams per pound of body weight (.5 gr./ kg. of weight), 13% of Caloric intake; or 10-15% of diet. |
| Blood Albumin is produced by human growth hormone (HGH) metabolite IgF-1 for body homeostatic balance; regulates watermetabolism, stabilizes blood and blood pH, carries nutrients and hormones to cells and wastes out, binds toxins and heavy metals, helps cell growth and repair, synthesizes proteins, an antioxidant that donates electrons, and buffers excess hormones. Albumin is depleted by infections and stress. SEE Albumin in Chapter Three Proteins. Blood oxidation is measured by Redox Potential - Relative Hydrogen (rH-) ranging from low 21 rH, to ideal 22, to 25. |
| Charcot-Marie-Tooth Syndrome Arareinheritedmuscle-wastingdisease; counterable with human growth hormone, RNA injections, and DHEA supplementation. Cheynes-Stokes breathing Abnormal breathing in some cerebral and heart disorders, with heavy agonized breathing alternated with suspension ofbreath. Cheilosis SEE Chloasma under Skin.
Chlorosis Anemia in girls at puberty causingyellow-greenish skin (green-sickness), and irregularmenses. Cholerine Mild cholera.
Chordee Frequentpainfulerection.and/orpenilecurvature.
Chorea Involuntary nervous, jerky muscle twitching (Woorara), SEE St. Vitus' dance. |
Jonny Bowden, M.A., C.N.S.
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 Important hormones (like human growth hormone) and neurotransmitters (like serotonin) simply don't get made in sufficient quantities if you're not sleeping soundly and deeply for at least seven to eight hours a night. Sleep is a weight loss drug. It has no bad side effects. And it's free!
8. Exercise every day. Not only will this increase your metabolic rate and burn calories, but doing it on a regular basis—at least five days a week—is the single best predictor of whether or not you will be successful in keeping weight off. |
Joseph E. Mario
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| NRG3 A neurotransmitter stimulating the pituitary gland precursing Human Growth Hormone; improves mental function, memory, reaction time, and well-being; gives pleasurable sensation lessening stress, depression, anger, despair, and addictions; blocks brain Dopamine release countering insomnia; improves athletic performance, muscle mass, and reduces fat; improves sense of touch, lowers sexual inhibitions in women, increases intensity of orgasm, and improves erections in males; reduces aging, improves the skin, and may reverse male pattern balding; contains 5 gr. |
Phyllis A. Balch, CNC
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| Human growth hormone (HGH) therapy has been shown to help prevent and /or reverse wasting syndrome. This treatment must be given under a doctor's supervision. (See growth hormone therapy in Part Three.)
Q Hyperbaric oxygen therapy is sometimes used, together with medications and other treatments, to help overcome opportunistic infections associated with AIDS. (See hyperbaric oxygen therapy in Part Three.)
Q N-acetylcysteine and L-carnitine both show some promise in the ability to prevent and counteract the extreme weight loss common in people with AIDS. |
| The body's pattern of melatonin production is similar to that of the other "antiaging" hormones, human growth hormone (HGH) and dehydroepiandrosterone (DHEA). Throughout early life, melatonin is produced in abundance. It was thought for some time that the production of melatonin begins to drop at puberty, and then continues to decline steadily as we age. This may not be true, according to research done at the Harvard Medical School. Researchers say that older people who were on aspirin therapy might have skewed the results because taking aspirin reduces melatonin levels in the body. |
Joseph E. Mario
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| SEE Bioflavonoids in Chapter One, Neurotransmitters, human growth hormone (HGH). and Antioxidants in this Chapter.
AREAS FAVORING LONGEVITY AND HEALTH
Valley ofthe Hunza, Himalaya mountains of Asia, where resident Hunzakuts I ive 120 years and procreate at 100 years.
Mountainous Tibetan residents live over 100 years.
Residents of mountainous Russian Georgia 1 ive over 100 years.
Northeast Africa, people have super hearing and health.
Valleys of Columbia, South America, where residents live 140-160 years in valleys surroundedbymountains, the soil isminimallyleachedoutby rain and water. |
Peter Rost
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| Genotropin, a human growth hormone, but also for global marketing of the same product. Sales of Genotropin were expected to top $600 million around the world, making ours one of the largest franchises within Pharmacia. In addition to my U.S. marketing staff, I also had a research group located in Sweden reporting to me. My work that summer in 2002 had taken me back to my native country and its capital city, Stockholm.
I was in a pretty good mood. |
| Genentech settled a similar case for their human growth hormone related to same issues during 1985-1994 for $50 million. Pharmacia sales reps who did not agree to off-label promotion were fired or other adverse action was taken against them. We also have compliance records from sales reps indicating in writing that they had been forced to do off-label promotion. Pharmacia also actively encouraged off-label prescriptions through favorable contracts with distributors and doctors exclusively working in the anti-aging area. |
KC Craichy
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 Don't be fooled by companies that market the benefits of human growth hormone (GH/HGH) in a pill, as it is mostly unsubstantiated hype. The benefits of growth hormone are well established, but what these companies are selling is not GH/HGH—it is what is known as amino acid secretagogues, or nutrient hormone precursors that the body uses in its production of GH/HGH. There is a thread of truth to the hype—certain amino acids taken in high dose on an empty stomach at bedtime can increase production of GH/HGH in the body. |
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